Offset Wrist Pin Affect Timing?

Pin offset is, or was, somewhat common to reduce skirt slap. Flipping the piston to improve the rod angle on the firing stroke, at the expense of noise and wear, has been around since the 50’s. It only makes sense if you are competing in a race class that requires all stock engine parts. It won’t produce any benefit you can feel, but it will be noisier. Smokey Yunick employed it in the early NASCAR years.